Can You Be Allergic to CBD?

Can you be allergic to cbd


Great question and the vast majority of CBD brands might be making the problem worse.


By vast majority, we're estimating in the 90 percentile!


We'll explain later.


There's lots of great research on CBD and the immune system, allergies, and histamines.


Of course, mast cells figure right into this nonsense.


We'll get into it below.


Most importantly, we'll touch base on why so many people may have allergic responses when taking "CBD".


The parentheses are not just there for looks or emphasis.


The type of "CBD" has a huge bearing on the potential for allergic reactions.


Let's get into it.

 compare cbd isolate options

Here are the topics:

  • Quick intro to the allergic reaction process
  • Can a person be allergic to CBD
  • Allergies to Full Spectrum CBD
  • Allergic to hemp oil
  • Allergic to CBD isolate
  • Can you get allergic hives from CBD
  • Can dogs be allergic to CBD

Quick intro to the allergic reaction process

To really see how allergies may or may not be caused by CBD, we need background.


The allergic response is actually part of our immune system.


It primarily resides in the mast cells!


Mast cells are special cells throughout the body that are designed to look for foreign entities as a sign of attack.

They're guards so to speak on the lookout for bacteria, viruses, and other intruders.


Their role is to get that stuff out of the body any which way they can.


Watery eyes. Sneezing. Coughing. Hives. Swelling. Etc.


We know all too well what the "symptoms" are but this is just the M.O. of mast cells.


It's the primary trick they know!


We can appreciate it with a bee sting but dander??


One of the key weapons Mast Cells has is histamine.


Histamine is a hormone released from these cells when triggered.


It's the key root of all these allergic reactions in the body.


Interestingly, histamine is excitatory in the brain there's a whole discussion on CBD for histamine and anxiety here.


Also, check out how the right CBD can actually help with allergies and histamines here.


So that's the 101 on our body's allergic reaction. the question at hand…


Can you have an allergic reaction to CBD?

Can a person be allergic to CBD

First, we need to really define "CBD oil".


We want to focus on just CBD isolate itself.


This is where it gets confusing since CBD oil is not regulated.


People are usually taking in lots of other stuff with their "CBD oil".


Let's talk about allergies based on three main ways people take CBD:

  • Full-spectrum CBD oil
  • Hemp oil
  • CBD isolate


These three options will have a very different allergy and histamine profiles.


Let's look at each.

Full Spectrum CBD and allergic response

Basically, with full-spectrum, you have a lot more of the hemp plant material in the oil.


This gives plenty more ways to have an allergic reaction.


Full Spectrum CBD is allowed to have up to .3% THC which is a known allergen.


Here's the deal...if you have other allergies, there's a good chance you'll have a reaction to cannabis in its raw form.


A study showed that 70% of the 50 million Americans with allergies will have a reaction to cannabis.


It's not just the THC.


It's a plant after all and plant material is a known issue for people with allergies.


It turns out that there are proteins in the plant that set off the allergic reaction to cannabis.


One note...CBD oil is derived from hemp which is just another name for cannabis with less than .3% THC.


Full-spectrum CBD is basically extracted CBD added back into hemp oil.


It's a way to jack up the CBD volume above what naturally occurs in the plant to get a baseline amount.


You can learn all about full-spectrum CBD and histamines here.


It's the hemp oil that's the issue!


Speaking of which….

Hemp oil and allergic reaction

If full-spectrum is hemp oil with CBD added to increase volume of CBD amounts, hemp oil is just the oil.


It's amazing for us.


Millions of Americans are using hemp oil and a good percentage of them are probably allergic to it.


They're buying hemp oil to feel better after all!


Almost all the research is on CBD and THC.


Just google "hemp oil NIH" and it will all be CBD (and maybe THC).


CBD is very different, even directly opposite to THC.


THC has some known issues (new report on how it affects Sperm gene pathways just today!).


Check out our article on CBD versus THC or why you must take CBD if you use cannabis.


The research on CBD has been remarkably positive.


Research on "hemp oil"??


Not much of it.


There may be lots of good stuff in there but not if you're prone to allergies.


This is especially true for:

  • Women (allergies and histamine issues have a significant gender effect)
  • Adults over 40 (falling hormones affect allergic sensitivities)
  • People allergic to other substances


It's all one system in terms of how we respond to allergies.


Hemp oil has all the same allergy-provoking proteins we mentioned in full-spectrum CBD.

shop and compare isolate cbd online

 So...what about CBD by itself?  Isolate?

Allergic response to CBD Isolate

CBD isolate usually refers to CBD the chemical, being added to a base oil.


The common base oils are:

  • MCT oil (extract from coconut oil)
  • Hemp oil
  • Olive oil


You can also get just CBD as a crystal (it's raw form) but this is not as popular since it's more difficult to deal with.


Obviously, the hemp and olive oil may pose the same issues we discussed above with just hemp oil.


MCT oil is an extract from coconut oil.


It's basically medium-chain fats from coconut oil.


CBD is best absorbed in the presence of fats (see CBD and food article).


The key with MCT oil is that it's an extract rather than the full plant material.


Coconut is technically a fruit and not a tree nut.


Let's look at just the cannabidiol (CBD) itself.


Allergic responses to the cannabidiol chemical itself.


Keep in mind that for any given substance under the sun, there's someone somewhere who is allergic to it.


Our immune response is incredibly complex with inputs going back to the womb and maybe even past generations!!


That being said, CBD is a chemical.


It's not a plant material which is good news.


Our allergic response has been primarily owned by our environment over 100's of thousands of years.


You don't find much CBD in the wild although cannabis has been around for 1000's of years in ancient medicinal use (India and China traditions both have extensive use of it).


On the safety profile of cannabidiol, there are no reported results for allergic reactions.


A good indication of an allergic response to a substance can be found it it's "side effects" profile.


The four most common side effects are:

  • Lower blood pressure
  • Lightheadedness
  • Dry mouth
  • Drowsiness


The first two are related and point to research showing that CBD lowers blood pressure.


Drowsiness is the opposite effect of an allergic response which is usually an anxious or heightened effect (as we know all too well).


Remember that histamine is excitatory and actually battles GABA to control the sleep/wake cycle (see CBD boost GABA).


Cannabidiol has a powerful anti-anxiety effect which you learn about at the CBD benefits for anxiety article here.


In fact, research is showing that cannabidiol has a powerful ANTI-histamine effect.


Learn all about CBD and histamines here.


There are studies showing that cannabidiol can significantly reduce the symptoms of allergic responses across different systems in the body but most importantly….


It helps to move the immune response from T1 to T2 which is directly tied to allergic responses.


It's a big reason why your friend can have a cat but you can't.


Again, if you're reading about allergies, check out the CBD and histamines article. It's fascinating.

How to avoid an allergic response to CBD

So here's the net net.


If you have allergic issues, focus on CBD isolate.


That's why we deal with CBD isolate at IndigoNaturals.


So many people with allergy or histamine issues are being "sold" on full-spectrum and feeling terrible from it.


That's going the wrong way!


Stay away from hemp oil and/or as much "plant" material as you can.


Always test first to see how your body responds.

The CBD must absolutely be 3rd party tested free of:

  • Solvents
  • Heavy metals
  • Pesticides
  • THC (known allergen)
  • Bacteria
  • Mold


This is a MUST HAVE when choosing CBD.


If the brand doesn't make this readily available, run...don't walk.


We actually test our CBD oils twice (once at the biomass and again for the finished product). 


The goal is better health after all.


Let's look at specific questions that come up with CBD and allergies. 

Can you get allergic hives from CBD

Yes but the same rules we discussed above hold true.


Our histamine pathway is system-wide.


It may rear its ugly head is specific areas (skin versus stomach versus sinuses, etc) but the chemical pathway is pretty similar.


Hives is just an allergic reaction in our skin.


This may apply more for topical applications directly to the skin or it can be systemic (think of how poison oak moves around the body).


You can test CBD oil directly on the skin to see how you react.


We always recommend going slow when starting anyway. Check out our How to Take CBD article.


We've seen countless situations where a person has an allergic response to full-spectrum CBD or hemp oil which goes away with CBD Isolate.


Just read our reviews.  Half of them involve this positive difference in response.


That's the primary reason we created IndigoNaturals...nearly full bottles of very big brands are lying around in a box somewhere.


Learn why you should only take CBD Isolate versus full-spectrum for histamines and allergies here

Can dogs or cats be allergic to CBD

Nature's pretty amazing.

When it finds something that works, it keeps it!


Every mammal has limbs composed of 1 large upper bone, connected to 2 lower limb bones, connected to a section of smaller "rock-line" bones and then 5 digits.


It's the same blueprint in us, a bat, a horse, or a whale.

  • The horse's hoof is one giant toenail (the other digits are shrunken).
  • The bat's wing has elongated digits with the skin between for wings.
  • The whale has shrunken all of this inside of a flipper.


Pretty cool!!  But we digress!


We share more than this with dogs and cats.


Most multicellular creatures have an endocannabinoid system that CBD interacts with.


It's dated at about 600,000 years old.


Sorry insects, you came too early to the party!


Dogs and cats also have very similar pathways to us in terms of how CBD works.


They share allergic responses as well since those pathways are the same although probably more robust in cats and dogs.


The same rules above hold true for cats and dogs in terms of allergies to CBD in its different forms!


Check out the Full spectrum versus CBD isolate histamine comparison here.


CBD Isolate in MCT oil (just two ingredients) with no other additives here:

shop cbd isolate oil online

Always work with a doctor or naturopath with any supplement!

The information provided here is not intended to treat an illness or substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.



Back to blog


Technically the FDA counts coconut as a tree nut, although most people with tree nut allergies can safely have coconut. No other nuts are processed in the same facility. We do use coconut oil as a base.


Is this product processed in a facility that is peanut and tree nut free.

Roger Phan

Leave a comment

Please note, comments need to be approved before they are published.